Despite Rome being an ancient city, it is far more wheelchair accessible than most people might think. It has all the accessible modes of transportation that one could find in any modern city. Sure, sometimes they might be makeshift accommodations, but the basics are there and from my experience, people are usually willing to lend a hand with getting in and out of vehicles if needed.
I’ve been to Rome twice now and so have had the opportunity to try more than a few public and private accessible transportation options. Here they are: